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Nutzung der biologischen Vielfalt von Pilzen zur Entdeckung neuartiger Antibiotika.

Nutzung der biologischen Vielfalt von Pilzen zur Entdeckung neuartiger Antibiotika.

Pilze gehörten zu den ersten Quellen für Antibiotika. Die Entdeckung und Entwicklung der β-Lactame vom Penicillin-Typ und Cephalosporin-Typ und ihrer synthetischen Versionen war für die Entstehung der modernen Pharmaindustrie transformativ. Sie bleiben auch 70 Jahre nach ihrer Entdeckung einige der wichtigsten Antibiotika. Inzwischen wurden Tausende von Pilzmetaboliten entdeckt, doch diese Metaboliten haben nur wenige zusätzliche Verbindungen beigetragen, die in die klinische Entwicklung eingetreten sind. In den letzten 15 Jahren nach dem Ausstieg der meisten großen Pharmaunternehmen aus dem Bereich der Entdeckung neuartiger Antibiotika wurden erhebliche Fortschritte bei der Bewertung der biologischen Vielfalt von Pilzen sowie die Verfügbarkeit moderner “-OMICS” -Technologie und revolutionäre Entwicklungen in der Pilzbiotechnologie erzielt.

Daher scheint der Zeitpunkt günstig zu sein, um diese faszinierenden chemisch reichen Organismen als Reservoir niedermolekularer Templates für die Entdeckung von Blei erneut zu betrachten. In dieser Übersicht werden laufende interdisziplinäre Szenarien beschrieben, in denen Spezialisten für Pilzbiologie mit Chemikern, Pharmakologen sowie Biochemie- und Prozessingenieuren zusammenarbeiten, um neue Antibiotika aufzudecken und herzustellen. Die Nützlichkeit eines Vorauswahlprozesses, der auf phylogenetischen Daten und der Verteilung des für den Gencluster kodierenden Sekundärmetaboliten basiert, wird hervorgehoben. Beispiele für neuartige bioaktive Metaboliten von Pilzen, die aus speziellen ökologischen Gruppen stammen, und neue phylogenetische Linien werden ebenfalls diskutiert.

L-Aminosäuren finden in der Biotechnologie verschiedene Anwendungen. L-Glutaminsäure und ihre Salze werden als Geschmacksverstärker verwendet. Andere L-Aminosäuren werden als Lebensmittel- oder Futtermittelzusatzstoffe, in der parenteralen Ernährung oder als Bausteine ​​für die chemische und pharmazeutische Industrie verwendet. L-Aminosäuren werden aus Vorläufern des zentralen Kohlenstoffmetabolismus synthetisiert. Basierend auf der Kenntnis der biochemischen Wege wurden mikrobielle Fermentationsprozesse von Lebensmittel-, Futtermittel- und Pharmaaminosäuren entwickelt. Die Produktionsstämme von Corynebacterium glutamicum, das seit mehr als 50 Jahren in der Lebensmittelbiotechnologie sicher eingesetzt wird, und Escherichia coli werden mithilfe metabolischer Verfahren ständig verbessert. Die Forschung nach neuen Prozessen ist im Gange. Die fermentative Produktion von L-Aminosäuren im Millionen-Tonnen-Maßstab hat die moderne Biotechnologie geprägt und ihre Märkte wachsen stetig weiter. Diese Übersicht konzentriert sich auf die jüngsten Erfolge bei der Stammentwicklung für die Aminosäureproduktion, einschließlich der Verwendung von CRISPRi / dCas9, genomreduzierten Stämmen, Biosensoren und Synthesewegen, um die Nutzung alternativer Kohlenstoffquellen zu ermöglichen.

 

Pharma-Erfolg in der Produktentwicklung – Verändert die Biotechnologie das Paradigma in der Produktentwicklung und Abnutzung?

Das Biotechnologiesegment der gesamten Biopharmaindustrie besteht seit nur etwa 40 bis 45 Jahren als Treiber für die Entwicklung neuer Produkte. Diese treibende Kraft wurde mit der FDA-Zulassung von rekombinantem Humaninsulin im Jahr 1982 initiiert, das von der Firma Genentech stammt. Die Pharmaindustrie beschäftigte sich in den frühen Jahren der 1970er und 1980er Jahre nur in geringem Maße mit Biotechnologieunternehmen, indem sie einige rekombinante Moleküle unter der Leitung von Roche, Eli Lilly sowie Johnson und Johnson einlizenzierte. Später und dramatisch in den letzten 25 Jahren hat sich die Biotechnologie jedoch zu einem Haupttreiber für Produkt- und Technologieinnovationen entwickelt und ist zu einem Eckpfeiler bei der Entwicklung neuer Produkte durch alle Biopharma-Unternehmen geworden.

Diese Überprüfung zeigt diese evolutionären Änderungen in Bezug auf zugelassene Produkte, Produktpipelines, Neuheit der Produkte, FDA-Zulassungsraten, Produktverkäufe, finanzielle F & E-Investitionen in Biotechnologie, Partnerschaften, Fusionen und Übernahmen sowie Patentfragen. Wir haben jetzt ungefähr 300 in den USA zugelassene Biotechnologieprodukte für 16 medizinische Disziplinen und ungefähr 250 Indikationen, an denen 25 Pharmaunternehmen sowie deren Innovatoren und Partner aus dem Biotechnologieunternehmen beteiligt sind. Die Biotechnologie-Pipeline umfasst über 1000 Moleküle in klinischen Studien, darunter über 300 Moleküle, die mit den Top-10-Pharmaunternehmen verbunden sind. Die Produktzulassungsraten der FDA für Biotechnologieprodukte sind mehr als doppelt so hoch wie für Arzneimittel. Ja, das F & E-Paradigma hat sich mit der Biotechnologie geändert, da einer der Hauptschwerpunkte für die Entwicklung neuer Produkte mit neuartigen Molekülen der gesamten Biopharmaindustrie ist.

Nutzung der biologischen Vielfalt von Pilzen zur Entdeckung neuartiger Antibiotika.

Relevanz der Grenzflächenviskoelastizität für die Stabilität und Konformation biomolekularer Organe an der Luft / Flüssigkeits-Grenzfläche.

Weiche Materialien sind komplexe makromolekulare Systeme, die häufig verwirrende nicht-Newtonsche viskoelastische Eigenschaften aufweisen, insbesondere wenn die Makromoleküle verwickelt, überfüllt oder vernetzt sind. Diese Materialien sind in der Biologie, Lebensmittel- und Pharmaindustrie allgegenwärtig und finden verschiedene Anwendungen in der Biotechnologie und auf dem Gebiet der Biosensoren. Basierend auf den Längenskalen, Topologien, Flexibilität und Konzentration verhalten sich die Systeme sowohl als Flüssigkeiten (viskos) als auch als Feststoffe (elastisch).

Insbesondere für Proteine ​​und Protein-Lipid-Systeme ist die Viskoelastizität ein wichtiger Parameter, da sie häufig direkt mit der Stabilität und den thermodynamischen Wechselwirkungen der reinen biologischen Komponenten sowie ihrer Gemische zusammenhängt. Trotz der umfangreichen Arbeit, die in der Lösungsmakrorheometrie verfügbar ist, gibt es immer noch eine Reihe von Problemen, die beim Umgang mit Proteinen an Luft / Flüssigkeits-Grenzflächen und mit Protein-Polymer- oder Protein-Lipid-Grenzflächen, die häufig sehr stark sind, angegangen werden müssen niedrige Grenzflächenviskositätswerte. In Anbetracht der wichtigen Anwendungen, die sie in der biopharmazeutischen, biotechnologischen und nutrazeutischen Industrie haben, besteht ein Bedarf an der Entwicklung von Methoden, die die folgenden drei spezifischen Probleme erfüllen: kleines Volumen, großer dynamischer Bereich der Schergeschwindigkeiten und Grenzflächeneigenschaften verschiedener Biomoleküle. Ferner sollten die Techniken, die entwickelt werden, Newtonsche, Scherverdünnungs- und Ausbeuteeigenschaften umfassen, die repräsentativ für das unterschiedliche Lösungsverhalten sind, das typischerweise auftritt.

Desmin Antibody

DF6138 200ul
EUR 420

Desmin Antibody

AF5334 200ul
EUR 420

Desmin Antibody

AF0147 200ul
EUR 420

Desmin antibody

70R-3807 50 ug
EUR 560.4
Description: Rabbit polyclonal Desmin antibody raised against the middle region of DES

Desmin antibody

70R-49656 100 ul
EUR 292.8
Description: Purified Polyclonal Desmin antibody

Desmin antibody

70R-36046 100 ug
EUR 392.4
Description: Rabbit polyclonal Desmin antibody

Desmin antibody

70R-31159 100 ug
EUR 392.4
Description: Rabbit polyclonal Desmin antibody

Desmin Antibody

48577-100ul 100ul
EUR 399.6

Desmin Antibody

48577-50ul 50ul
EUR 286.8

Desmin Antibody

48749-100ul 100ul
EUR 399.6

Desmin Antibody

48749-50ul 50ul
EUR 286.8

Desmin Peptide

46-777P 0.1 mg
EUR 405.6
Description: Desmin Peptide

Desmin antibody

70R-10682 1 ml
EUR 447.6
Description: Rabbit polyclonal Desmin antibody

Desmin antibody

70R-1238 100 ug
EUR 452.4
Description: Rabbit polyclonal Desmin antibody raised against the N terminal of DES

Desmin protein

30R-2118 250 ug
EUR 864
Description: Purified recombinant Human Desmin protein

Desmin protein

30R-2129 100 ug
EUR 391.2
Description: Purified native Chicken Desmin Protein

Desmin protein

30R-2138 100 ug
EUR 558
Description: Purified recombinant Human Desmin protein

Desmin antibody

20R-DR029 500 ul
EUR 716.4
Description: Rabbit polyclonal Desmin antibody

Desmin antibody

10R-7851 100 ug
EUR 386.4
Description: Mouse monoclonal Desmin antibody

Desmin antibody

10R-7985 100 ug
EUR 495.6
Description: Mouse monoclonal Desmin antibody

Desmin antibody

10R-7986 100 ug
EUR 502.8
Description: Mouse monoclonal Desmin antibody

Desmin antibody

10R-2030 100 ul
EUR 418.8
Description: Mouse monoclonal Desmin antibody

Desmin antibody

10R-D101a 1 mL
EUR 657.6
Description: Mouse monoclonal Desmin antibody

Desmin Antibody

33355-100ul 100ul
EUR 302.4

Desmin Antibody

33355-50ul 50ul
EUR 224.4

Desmin Antibody

ABF0147 100 ug
EUR 525.6

Desmin Antibody

ABF5334 100 ug
EUR 525.6

Desmin Protein

20-abx261990
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Desmin Antibody

BF0078 200ul
EUR 540

Desmin protein

E20-80025 20ug
EUR 489.6

Desmin Antibody

R20261-0.1ML 100ul
EUR 409

Desmin Antibody

R30031 100 ug
EUR 419

Desmin Antibody

R31530 100 ug
EUR 419

Desmin Antibody

R35556-100UG 100 ug
EUR 399

Desmin Antibody

RQ5525 100 ug
EUR 419

Desmin Antibody

F48175-0.4ML 0.4 ml
EUR 379

Desmin Antibody

V9390-100UG 100ug
EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V9390-20UG 20ug
EUR 219
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V9390SAF-100UG 100ug
EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V9768-100UG 100ug
EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V9768-20UG 20ug
EUR 219
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V9768SAF-100UG 100ug
EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V3200-100UG 100 ug
EUR 349.3
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V3200-20UG 20 ug
EUR 153.3
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody

V3200SAF-100UG 100 ug
EUR 349.3
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Standard

abx098954-10vials 10 vials
EUR 2614.8

Standard

abx098954-1vial 1 vial
EUR 360

Standard

abx098954-5vials 5 vials
EUR 1412.4

Standard

abx098955-10vials 10 vials
EUR 2614.8

Standard

abx098955-1vial 1 vial
EUR 360

Standard

abx098955-5vials 5 vials
EUR 1412.4

Standard

abx098956-10vials 10 vials
EUR 2614.8

Standard

abx098956-1vial 1 vial
EUR 360

Standard

abx098956-5vials 5 vials
EUR 1412.4

Standard

abx098963-10vials 10 vials
EUR 2614.8

Standard

abx098963-1vial 1 vial
EUR 360

Standard

abx098963-5vials 5 vials
EUR 1412.4

Standard

abx098965-10vials 10 vials
EUR 2614.8

Standard

abx098965-1vial 1 vial
EUR 360

Standard

abx098965-5vials 5 vials
EUR 1412.4

Standard

abx098967-10vials 10 vials
EUR 2614.8

Standard

abx098967-1vial 1 vial
EUR 360

Standard

abx098967-5vials 5 vials
EUR 1412.4

Standard

abx098968-10vials 10 vials
EUR 2614.8

Standard

abx098968-1vial 1 vial
EUR 360

Standard

abx098968-5vials 5 vials
EUR 1412.4

Standard

abx098969-10vials 10 vials
EUR 2614.8

Standard

abx098969-1vial 1 vial
EUR 360

Standard

abx098969-5vials 5 vials
EUR 1412.4

Standard

abx092106-1vial 1 vial
EUR 260.4

Standard

abx296006-1vial 1 vial
EUR 360

Desmin Polyclonal Antibody

ABP51163-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Desmin at AA range: 390-470

Desmin Polyclonal Antibody

ABP51163-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Desmin at AA range: 390-470

Desmin Polyclonal Antibody

ABP51163-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Desmin at AA range: 390-470

Desmin Polyclonal Antibody

ABP51164-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Desmin around the non-phosphorylation site of S60

Desmin Polyclonal Antibody

ABP51164-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Desmin around the non-phosphorylation site of S60

Desmin Polyclonal Antibody

ABP51164-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Desmin around the non-phosphorylation site of S60

Desmin Conjugated Antibody

C33355 100ul
EUR 476.4

Desmin Blocking Peptide

AF5334-BP 1mg
EUR 234

Desmin Blocking Peptide

AF0147-BP 1mg
EUR 234

anti- Desmin antibody

FNab02340 100µg
EUR 606.3
Description: Antibody raised against Desmin

anti- Desmin antibody

FNab02341 100µg
EUR 658.5
Description: Antibody raised against Desmin

anti- Desmin antibody

FNab02342 100µg
EUR 658.5
Description: Antibody raised against Desmin

Desmin Monoclonal Antibody

EM1218-100ul 100ul
EUR 334.8
Description: A Mouse Monoclonal antibody against Desmin from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Desmin Monoclonal Antibody

EM1218-50ul 50ul
EUR 248.4
Description: A Mouse Monoclonal antibody against Desmin from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Desmin Polyclonal Antibody

ES2162-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Desmin Polyclonal Antibody

ES2162-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Desmin Polyclonal Antibody

ES2163-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Desmin Polyclonal Antibody

ES2163-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Desmin antibody (Ser60)

70R-35266 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal Desmin antibody (Ser60)

Recombinant Human Desmin

7-04975 5µg Ask for price

Recombinant Human Desmin

7-04976 20µg Ask for price

Recombinant Human Desmin

7-04977 1mg Ask for price

Desmin Recombinant Protein

92-030 0.05 mg
EUR 821.4
Description: Desmin is a cytoplasmic protein and belongs to the intermediate filament family. interacts with DST and MTM1. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. Desmin is the main intermediate filament in mature skeletal, cardiac and smooth-muscle cells. DES founctions as homopolymers to form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. .Defects in DES are cause of the myopathy myofibrillar type 1, cardiomyopathy dilated type 1I, and neurogenic scapuloperoneal syndrome Kaeser type.

Desmin protein (Chicken)

30R-AD003 250 ug
EUR 657.6
Description: Purified native Chicken Desmin protein

Desmin Polyclonal Antibody

40839-100ul 100ul
EUR 302.4

Desmin Polyclonal Antibody

40839-50ul 50ul
EUR 224.4

Desmin Blocking Peptide

33R-5684 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DES antibody, catalog no. 70R-3807

Desmin Blocking Peptide

33R-7209 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DES antibody, catalog no. 70R-1238

Desmin (Des) Antibody

20-abx100036
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Desmin (DES) Antibody

20-abx159470
  • EUR 326.40
  • EUR 276.00
  • 100 ug
  • 50 ug

Desmin (Des) Antibody

20-abx172093
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Desmin (Des) Antibody

20-abx172094
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Desmin (DES) Antibody

abx122581-100ug 100 ug
EUR 469.2

Desmin (DES) Antibody

20-abx125113
  • EUR 710.40
  • EUR 1028.40
  • EUR 260.40
  • EUR 493.20
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Desmin (DES) Antibody

20-abx125323
  • EUR 594.00
  • EUR 844.80
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 50 ul

Desmin (DES) Antibody

20-abx112046
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Desmin (DES) Antibody

20-abx000692
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Desmin (DES) Antibody

20-abx000834
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Desmin (DES) Antibody

abx020549-100ug 100 ug
EUR 560.4

Desmin (DES) Antibody

abx010636-100ul 100 ul
EUR 493.2

Desmin (DES) Antibody

20-abx013058
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Desmin (DES) Antibody

20-abx009339
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Desmin Blocking Peptide

20-abx062531
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Desmin (DES) Antibody

abx027938-400ul 400 ul
EUR 627.6

Desmin (DES) Antibody

abx027938-80l 80 µl
EUR 343.2

Desmin (DES) Antibody

abx031687-400ul 400 ul
EUR 627.6

Desmin (DES) Antibody

abx031687-80l 80 µl
EUR 343.2

Desmin (DESM) Antibody

abx025293-400ul 400 ul
EUR 627.6

Desmin (DESM) Antibody

abx025293-80l 80 µl
EUR 343.2

Anti-Desmin Antibody

A2001-100 100 µl
EUR 405.6

Desmin Monoclonal Antibody

ABM40221-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Desmin Monoclonal Antibody

ABM40221-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Desmin Monoclonal Antibody

ABM40221-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Desmin Rabbit mAb

A3736 20 μL
EUR 18

Desmin Rabbit mAb

A3736-100ul 100 ul
EUR 492

Desmin Rabbit mAb

A3736-200ul 200 ul
EUR 685.2

Desmin Rabbit mAb

A3736-20ul 20 ul
EUR 265.2

Desmin Rabbit mAb

A3736-50ul 50 ul
EUR 344.4

Desmin (DES) Antibody

abx232340-100ug 100 ug
EUR 577.2

Desmin (DES) Antibody

abx232341-100ug 100 ug
EUR 610.8

Desmin (DES) Antibody

abx232342-100ug 100 ug
EUR 610.8

Desmin (DES) Antibody

20-abx329232
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Desmin (DES) Antibody

abx431203-200ul 200 ul
EUR 460.8

Desmin (DES) Antibody

20-abx302193
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Die hier vorgestellte Übersicht ist eine umfassende Darstellung der rheologischen Eigenschaften verschiedener Biomoleküle an den Grenzflächen Luft / Flüssigkeit und Feststoff / Flüssigkeit. Es befasst sich mit der Nützlichkeit der “Viskoelastizität” der Systeme an den auf molekularer Ebene analysierten Grenzflächen, die mit den mikroskopischen Materialeigenschaften korreliert werden können, und geht auf einige neuere Techniken in der Mikrorheologie ein, mit denen die ungewöhnlich niedrigen Viskositätswerte empfindlich gemessen werden.

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