Pilze gehörten zu den ersten Quellen für Antibiotika. Die Entdeckung und Entwicklung der β-Lactame vom Penicillin-Typ und Cephalosporin-Typ und ihrer synthetischen Versionen war für die Entstehung der modernen Pharmaindustrie transformativ. Sie bleiben auch 70 Jahre nach ihrer Entdeckung einige der wichtigsten Antibiotika. Inzwischen wurden Tausende von Pilzmetaboliten entdeckt, doch diese Metaboliten haben nur wenige zusätzliche Verbindungen beigetragen, die in die klinische Entwicklung eingetreten sind. In den letzten 15 Jahren nach dem Ausstieg der meisten großen Pharmaunternehmen aus dem Bereich der Entdeckung neuartiger Antibiotika wurden erhebliche Fortschritte bei der Bewertung der biologischen Vielfalt von Pilzen sowie die Verfügbarkeit moderner “-OMICS” -Technologie und revolutionäre Entwicklungen in der Pilzbiotechnologie erzielt.

Daher scheint der Zeitpunkt günstig zu sein, um diese faszinierenden chemisch reichen Organismen als Reservoir niedermolekularer Templates für die Entdeckung von Blei erneut zu betrachten. In dieser Übersicht werden laufende interdisziplinäre Szenarien beschrieben, in denen Spezialisten für Pilzbiologie mit Chemikern, Pharmakologen sowie Biochemie- und Prozessingenieuren zusammenarbeiten, um neue Antibiotika aufzudecken und herzustellen. Die Nützlichkeit eines Vorauswahlprozesses, der auf phylogenetischen Daten und der Verteilung des für den Gencluster kodierenden Sekundärmetaboliten basiert, wird hervorgehoben. Beispiele für neuartige bioaktive Metaboliten von Pilzen, die aus speziellen ökologischen Gruppen stammen, und neue phylogenetische Linien werden ebenfalls diskutiert.

L-Aminosäuren finden in der Biotechnologie verschiedene Anwendungen. L-Glutaminsäure und ihre Salze werden als Geschmacksverstärker verwendet. Andere L-Aminosäuren werden als Lebensmittel- oder Futtermittelzusatzstoffe, in der parenteralen Ernährung oder als Bausteine ​​für die chemische und pharmazeutische Industrie verwendet. L-Aminosäuren werden aus Vorläufern des zentralen Kohlenstoffmetabolismus synthetisiert. Basierend auf der Kenntnis der biochemischen Wege wurden mikrobielle Fermentationsprozesse von Lebensmittel-, Futtermittel- und Pharmaaminosäuren entwickelt. Die Produktionsstämme von Corynebacterium glutamicum, das seit mehr als 50 Jahren in der Lebensmittelbiotechnologie sicher eingesetzt wird, und Escherichia coli werden mithilfe metabolischer Verfahren ständig verbessert. Die Forschung nach neuen Prozessen ist im Gange. Die fermentative Produktion von L-Aminosäuren im Millionen-Tonnen-Maßstab hat die moderne Biotechnologie geprägt und ihre Märkte wachsen stetig weiter. Diese Übersicht konzentriert sich auf die jüngsten Erfolge bei der Stammentwicklung für die Aminosäureproduktion, einschließlich der Verwendung von CRISPRi / dCas9, genomreduzierten Stämmen, Biosensoren und Synthesewegen, um die Nutzung alternativer Kohlenstoffquellen zu ermöglichen.

 

Pharma-Erfolg in der Produktentwicklung – Verändert die Biotechnologie das Paradigma in der Produktentwicklung und Abnutzung?

Das Biotechnologiesegment der gesamten Biopharmaindustrie besteht seit nur etwa 40 bis 45 Jahren als Treiber für die Entwicklung neuer Produkte. Diese treibende Kraft wurde mit der FDA-Zulassung von rekombinantem Humaninsulin im Jahr 1982 initiiert, das von der Firma Genentech stammt. Die Pharmaindustrie beschäftigte sich in den frühen Jahren der 1970er und 1980er Jahre nur in geringem Maße mit Biotechnologieunternehmen, indem sie einige rekombinante Moleküle unter der Leitung von Roche, Eli Lilly sowie Johnson und Johnson einlizenzierte. Später und dramatisch in den letzten 25 Jahren hat sich die Biotechnologie jedoch zu einem Haupttreiber für Produkt- und Technologieinnovationen entwickelt und ist zu einem Eckpfeiler bei der Entwicklung neuer Produkte durch alle Biopharma-Unternehmen geworden.

Diese Überprüfung zeigt diese evolutionären Änderungen in Bezug auf zugelassene Produkte, Produktpipelines, Neuheit der Produkte, FDA-Zulassungsraten, Produktverkäufe, finanzielle F & E-Investitionen in Biotechnologie, Partnerschaften, Fusionen und Übernahmen sowie Patentfragen. Wir haben jetzt ungefähr 300 in den USA zugelassene Biotechnologieprodukte für 16 medizinische Disziplinen und ungefähr 250 Indikationen, an denen 25 Pharmaunternehmen sowie deren Innovatoren und Partner aus dem Biotechnologieunternehmen beteiligt sind. Die Biotechnologie-Pipeline umfasst über 1000 Moleküle in klinischen Studien, darunter über 300 Moleküle, die mit den Top-10-Pharmaunternehmen verbunden sind. Die Produktzulassungsraten der FDA für Biotechnologieprodukte sind mehr als doppelt so hoch wie für Arzneimittel. Ja, das F & E-Paradigma hat sich mit der Biotechnologie geändert, da einer der Hauptschwerpunkte für die Entwicklung neuer Produkte mit neuartigen Molekülen der gesamten Biopharmaindustrie ist.

Relevanz der Grenzflächenviskoelastizität für die Stabilität und Konformation biomolekularer Organe an der Luft / Flüssigkeits-Grenzfläche.

Weiche Materialien sind komplexe makromolekulare Systeme, die häufig verwirrende nicht-Newtonsche viskoelastische Eigenschaften aufweisen, insbesondere wenn die Makromoleküle verwickelt, überfüllt oder vernetzt sind. Diese Materialien sind in der Biologie, Lebensmittel- und Pharmaindustrie allgegenwärtig und finden verschiedene Anwendungen in der Biotechnologie und auf dem Gebiet der Biosensoren. Basierend auf den Längenskalen, Topologien, Flexibilität und Konzentration verhalten sich die Systeme sowohl als Flüssigkeiten (viskos) als auch als Feststoffe (elastisch).

Insbesondere für Proteine ​​und Protein-Lipid-Systeme ist die Viskoelastizität ein wichtiger Parameter, da sie häufig direkt mit der Stabilität und den thermodynamischen Wechselwirkungen der reinen biologischen Komponenten sowie ihrer Gemische zusammenhängt. Trotz der umfangreichen Arbeit, die in der Lösungsmakrorheometrie verfügbar ist, gibt es immer noch eine Reihe von Problemen, die beim Umgang mit Proteinen an Luft / Flüssigkeits-Grenzflächen und mit Protein-Polymer- oder Protein-Lipid-Grenzflächen, die häufig sehr stark sind, angegangen werden müssen niedrige Grenzflächenviskositätswerte. In Anbetracht der wichtigen Anwendungen, die sie in der biopharmazeutischen, biotechnologischen und nutrazeutischen Industrie haben, besteht ein Bedarf an der Entwicklung von Methoden, die die folgenden drei spezifischen Probleme erfüllen: kleines Volumen, großer dynamischer Bereich der Schergeschwindigkeiten und Grenzflächeneigenschaften verschiedener Biomoleküle. Ferner sollten die Techniken, die entwickelt werden, Newtonsche, Scherverdünnungs- und Ausbeuteeigenschaften umfassen, die repräsentativ für das unterschiedliche Lösungsverhalten sind, das typischerweise auftritt.

Desmin Antibody
DF6138	Affbiotech	200ul	EUR 420

Desmin Antibody
AF5334	Affbiotech	200ul	EUR 420

Desmin Antibody
AF0147	Affbiotech	200ul	EUR 420

Desmin antibody
70R-3807	Fitzgerald	50 ug	EUR 560.4
Description: Rabbit polyclonal Desmin antibody raised against the middle region of DES

Desmin antibody
70R-49656	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal Desmin antibody

Desmin antibody
70R-36046	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal Desmin antibody

Desmin antibody
70R-31159	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal Desmin antibody

Desmin Antibody
48577-100ul	SAB	100ul	EUR 399.6

Desmin Antibody
48577-50ul	SAB	50ul	EUR 286.8

Desmin Antibody
48749-100ul	SAB	100ul	EUR 399.6

Desmin Antibody
48749-50ul	SAB	50ul	EUR 286.8

Desmin Peptide
46-777P	ProSci	0.1 mg	EUR 405.6
Description: Desmin Peptide

Desmin antibody
70R-10682	Fitzgerald	1 ml	EUR 447.6
Description: Rabbit polyclonal Desmin antibody

Desmin antibody
70R-1238	Fitzgerald	100 ug	EUR 452.4
Description: Rabbit polyclonal Desmin antibody raised against the N terminal of DES

Desmin protein
30R-2118	Fitzgerald	250 ug	EUR 864
Description: Purified recombinant Human Desmin protein

Desmin protein
30R-2129	Fitzgerald	100 ug	EUR 391.2
Description: Purified native Chicken Desmin Protein

Desmin protein
30R-2138	Fitzgerald	100 ug	EUR 558
Description: Purified recombinant Human Desmin protein

Desmin antibody
20R-DR029	Fitzgerald	500 ul	EUR 716.4
Description: Rabbit polyclonal Desmin antibody

Desmin antibody
10R-7851	Fitzgerald	100 ug	EUR 386.4
Description: Mouse monoclonal Desmin antibody

Desmin antibody
10R-7985	Fitzgerald	100 ug	EUR 495.6
Description: Mouse monoclonal Desmin antibody

Desmin antibody
10R-7986	Fitzgerald	100 ug	EUR 502.8
Description: Mouse monoclonal Desmin antibody

Desmin antibody
10R-2030	Fitzgerald	100 ul	EUR 418.8
Description: Mouse monoclonal Desmin antibody

Desmin antibody
10R-D101a	Fitzgerald	1 mL	EUR 657.6
Description: Mouse monoclonal Desmin antibody

Desmin Antibody
33355-100ul	SAB	100ul	EUR 302.4

Desmin Antibody
33355-50ul	SAB	50ul	EUR 224.4

Desmin Antibody
ABF0147	Lifescience Market	100 ug	EUR 525.6

Desmin Antibody
ABF5334	Lifescience Market	100 ug	EUR 525.6

Desmin Protein
20-abx261990	Abbexa	EUR 5388.00 EUR 393.60 EUR 276.00	1 mg 20 ug 5 ug

Desmin Antibody
BF0078	Affbiotech	200ul	EUR 540

Desmin protein
E20-80025	EnoGene	20ug	EUR 489.6

Desmin Antibody
R20261-0.1ML	NSJ Bioreagents	100ul	EUR 409

Desmin Antibody
R30031	NSJ Bioreagents	100 ug	EUR 419

Desmin Antibody
R31530	NSJ Bioreagents	100 ug	EUR 419

Desmin Antibody
R35556-100UG	NSJ Bioreagents	100 ug	EUR 399

Desmin Antibody
RQ5525	NSJ Bioreagents	100 ug	EUR 419

Desmin Antibody
F48175-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

Desmin Antibody
V9390-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V9390-20UG	NSJ Bioreagents	20ug	EUR 219
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V9390SAF-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V9768-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V9768-20UG	NSJ Bioreagents	20ug	EUR 219
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V9768SAF-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V3200-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V3200-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Desmin Antibody
V3200SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Standard
abx098954-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098954-1vial	Abbexa	1 vial	EUR 360

Standard
abx098954-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx098955-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098955-1vial	Abbexa	1 vial	EUR 360

Standard
abx098955-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx098956-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098956-1vial	Abbexa	1 vial	EUR 360

Standard
abx098956-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx098963-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098963-1vial	Abbexa	1 vial	EUR 360

Standard
abx098963-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx098965-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098965-1vial	Abbexa	1 vial	EUR 360

Standard
abx098965-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx098967-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098967-1vial	Abbexa	1 vial	EUR 360

Standard
abx098967-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx098968-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098968-1vial	Abbexa	1 vial	EUR 360

Standard
abx098968-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx098969-10vials	Abbexa	10 vials	EUR 2614.8

Standard
abx098969-1vial	Abbexa	1 vial	EUR 360

Standard
abx098969-5vials	Abbexa	5 vials	EUR 1412.4

Standard
abx092106-1vial	Abbexa	1 vial	EUR 260.4

Standard
abx296006-1vial	Abbexa	1 vial	EUR 360

Desmin Polyclonal Antibody
ABP51163-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Desmin at AA range: 390-470

Desmin Polyclonal Antibody
ABP51163-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Desmin at AA range: 390-470

Desmin Polyclonal Antibody
ABP51163-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Desmin at AA range: 390-470

Desmin Polyclonal Antibody
ABP51164-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Desmin around the non-phosphorylation site of S60

Desmin Polyclonal Antibody
ABP51164-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Desmin around the non-phosphorylation site of S60

Desmin Polyclonal Antibody
ABP51164-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Desmin around the non-phosphorylation site of S60

Desmin Conjugated Antibody
C33355	SAB	100ul	EUR 476.4

Desmin Blocking Peptide
AF5334-BP	Affbiotech	1mg	EUR 234

Desmin Blocking Peptide
AF0147-BP	Affbiotech	1mg	EUR 234

anti- Desmin antibody
FNab02340	FN Test	100µg	EUR 606.3
Description: Antibody raised against Desmin

anti- Desmin antibody
FNab02341	FN Test	100µg	EUR 658.5
Description: Antibody raised against Desmin

anti- Desmin antibody
FNab02342	FN Test	100µg	EUR 658.5
Description: Antibody raised against Desmin

Desmin Monoclonal Antibody
EM1218-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Mouse Monoclonal antibody against Desmin from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Desmin Monoclonal Antibody
EM1218-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Mouse Monoclonal antibody against Desmin from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Desmin Polyclonal Antibody
ES2162-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Desmin Polyclonal Antibody
ES2162-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Desmin Polyclonal Antibody
ES2163-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Desmin Polyclonal Antibody
ES2163-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Desmin from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Desmin antibody (Ser60)
70R-35266	Fitzgerald	100 ug	EUR 392.4
Description: Purified Rabbit polyclonal Desmin antibody (Ser60)

Recombinant Human Desmin
7-04975	CHI Scientific	5µg	Ask for price

Recombinant Human Desmin
7-04976	CHI Scientific	20µg	Ask for price

Recombinant Human Desmin
7-04977	CHI Scientific	1mg	Ask for price

Desmin Recombinant Protein
92-030	ProSci	0.05 mg	EUR 821.4
Description: Desmin is a cytoplasmic protein and belongs to the intermediate filament family. interacts with DST and MTM1. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. Desmin is the main intermediate filament in mature skeletal, cardiac and smooth-muscle cells. DES founctions as homopolymers to form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. .Defects in DES are cause of the myopathy myofibrillar type 1, cardiomyopathy dilated type 1I, and neurogenic scapuloperoneal syndrome Kaeser type.

Desmin protein (Chicken)
30R-AD003	Fitzgerald	250 ug	EUR 657.6
Description: Purified native Chicken Desmin protein

Desmin Polyclonal Antibody
40839-100ul	SAB	100ul	EUR 302.4

Desmin Polyclonal Antibody
40839-50ul	SAB	50ul	EUR 224.4

Desmin Blocking Peptide
33R-5684	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DES antibody, catalog no. 70R-3807

Desmin Blocking Peptide
33R-7209	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DES antibody, catalog no. 70R-1238

Desmin (Des) Antibody
20-abx100036	Abbexa	EUR 477.60 EUR 159.60 EUR 1328.40 EUR 644.40 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Desmin (DES) Antibody
20-abx159470	Abbexa	EUR 326.40 EUR 276.00	100 ug 50 ug

Desmin (Des) Antibody
20-abx172093	Abbexa	EUR 944.40 EUR 493.20	1 mg 200 ug

Desmin (Des) Antibody
20-abx172094	Abbexa	EUR 1011.60 EUR 526.80	1 mg 200 ug

Desmin (DES) Antibody
abx122581-100ug	Abbexa	100 ug	EUR 469.2

Desmin (DES) Antibody
20-abx125113	Abbexa	EUR 710.40 EUR 1028.40 EUR 260.40 EUR 493.20	100 ul 200 ul 20 ul 50 ul

Desmin (DES) Antibody
20-abx125323	Abbexa	EUR 594.00 EUR 844.80 EUR 427.20	100 ul 200 ul 50 ul

Desmin (DES) Antibody
20-abx112046	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Desmin (DES) Antibody
20-abx000692	Abbexa	EUR 493.20 EUR 710.40	100 ul 200 ul

Desmin (DES) Antibody
20-abx000834	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Desmin (DES) Antibody
abx020549-100ug	Abbexa	100 ug	EUR 560.4

Desmin (DES) Antibody
abx010636-100ul	Abbexa	100 ul	EUR 493.2

Desmin (DES) Antibody
20-abx013058	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Desmin (DES) Antibody
20-abx009339	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Desmin Blocking Peptide
20-abx062531	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

Desmin (DES) Antibody
abx027938-400ul	Abbexa	400 ul	EUR 627.6

Desmin (DES) Antibody
abx027938-80l	Abbexa	80 µl	EUR 343.2

Desmin (DES) Antibody
abx031687-400ul	Abbexa	400 ul	EUR 627.6

Desmin (DES) Antibody
abx031687-80l	Abbexa	80 µl	EUR 343.2

Desmin (DESM) Antibody
abx025293-400ul	Abbexa	400 ul	EUR 627.6

Desmin (DESM) Antibody
abx025293-80l	Abbexa	80 µl	EUR 343.2

Anti-Desmin Antibody
A2001-100	Biovision	100 µl	EUR 405.6

Desmin Monoclonal Antibody
ABM40221-003ml	Abbkine	0.03ml	EUR 189.6
Description: A monoclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Desmin Monoclonal Antibody
ABM40221-01ml	Abbkine	0.1ml	EUR 346.8
Description: A monoclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Desmin Monoclonal Antibody
ABM40221-02ml	Abbkine	0.2ml	EUR 496.8
Description: A monoclonal antibody for detection of Desmin from Human, Mouse, Rat. This Desmin antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Desmin Rabbit mAb
A3736	Abclonal	20 μL	EUR 18

Desmin Rabbit mAb
A3736-100ul	Abclonal	100 ul	EUR 492

Desmin Rabbit mAb
A3736-200ul	Abclonal	200 ul	EUR 685.2

Desmin Rabbit mAb
A3736-20ul	Abclonal	20 ul	EUR 265.2

Desmin Rabbit mAb
A3736-50ul	Abclonal	50 ul	EUR 344.4

Desmin (DES) Antibody
abx232340-100ug	Abbexa	100 ug	EUR 577.2

Desmin (DES) Antibody
abx232341-100ug	Abbexa	100 ug	EUR 610.8

Desmin (DES) Antibody
abx232342-100ug	Abbexa	100 ug	EUR 610.8

Desmin (DES) Antibody
20-abx329232	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Desmin (DES) Antibody
abx431203-200ul	Abbexa	200 ul	EUR 460.8

Desmin (DES) Antibody
20-abx302193	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Die hier vorgestellte Übersicht ist eine umfassende Darstellung der rheologischen Eigenschaften verschiedener Biomoleküle an den Grenzflächen Luft / Flüssigkeit und Feststoff / Flüssigkeit. Es befasst sich mit der Nützlichkeit der “Viskoelastizität” der Systeme an den auf molekularer Ebene analysierten Grenzflächen, die mit den mikroskopischen Materialeigenschaften korreliert werden können, und geht auf einige neuere Techniken in der Mikrorheologie ein, mit denen die ungewöhnlich niedrigen Viskositätswerte empfindlich gemessen werden.